New Drug Tested On Mice Might Stop Baldness and Bad Skin

In a test carried out on mice, scientists from John Hopkins used a new compound named (D-PDMP) to stop baldness. Studies also link these problems to unhealthy food high in fats.
As a study shows that mice fed with fatty food had higher chance of having grey hair, baldness, and sore skin. But When the mice took the compound, these health problems stopped.
These scientists explained that this compound stops the creation of certain fats (GSLs) contained in our cells and skin. According to the research, although it gave positive results in mice, it does not mean it will work on humans perfectly. They also add that the compounds might pose a dangerous effect on humans. But the study shows how drugs and creams might help fight sore skin and hair loss.

A report on the conclusion of the experiment published in the July 30 edition says:
Further research is needed, but our findings show promise for someday using the drug we developed for skin diseases such as psoriasis, and wounds resulting from diabetes or plastic surgery,” says Subroto Chatterjee, a senior member of the John Hopkins research team.

Older studies tells us that GSLs occur in large numbers in cells that form the top layer of the skin. They also occur in cells that control our skin, eye and hair color.

When the researchers wanted to discover how GSLs affects the skin and the possible ways to treat related problems, mice with heart diseases were made available. They then fed the mice food rich in unhealthy fat while the second group ate regular chow. All the animals ate these foods from ages 12 weeks to 20 weeks.

When compared to those fed regular food, the mice that ate the fatty diet became bald, had skin wounds and a change of hair color. These signs become worse as they continued eating the fatty foods. More than half of the animals had these symptoms.

The mice in both groups were then given a compound (D-PDMP) in both liquid and capsule forms while they were on the same diet. Results showed that the mice given the compounds stopped having adverse effects caused by such foods. The results also showed that capsules containing the compound performed better than the liquid.

With the use of microscopes, the research team saw that mice eating the fatty diet had skins that contained cells that harm them. Using the D-PDMP capsules containing the chemical compound reduced the number of toxic cells which made the sore skin heal.

Next, the team performed tests to know the levels of chemicals that protect the skin and also those that make it sore. Reports show that the mice with delicate skin saw an increase in the number of good fats that keep the skin safe. This situation happened after they took capsules of D-PDMP.

Our findings show that a Western diet causes hair loss, hair whitening and skin inflammation in mice, and we believe a similar process occurs in men who lose hair and experience hair whitening when they eat a diet high in fat and cholesterol” says Chatterjee.

More animal research needs to be done to confirm and expand on the findings to determine how well and what amount of D-PDMP might heal wounds and activate hair growth.

However, the team supports the setting up of more animal tests to gain more knowledge regarding the issue. They also would like these future tests to show how the drug can heal sores and help human hair growth.

Hopefully someday in the future, this can mean faster, more effective recovery from baldness, hair whitening in aging populations and wound healing” says Chatterjee.

Source: https://www.sciencedaily.com/releases/2018/07/180730090152.htm

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