European Hair Research Society

Source for European Hair Research Society

Purpose

This genetic study will involve a comprehensive, genome-wide screen of DNA isolated from blood samples provided by donors. Statistical analysis of the results will provide information on areas of the human genome where genes involved in AA are located. With this information, and using data from the recently completed human genome mapping project, candidate genes can later be defined and examined in detail to evaluate how they may be involved in alopecia areata.

Eligibility

This study needs the participation of at least 1120 volunteers in 280 family groups to ensure reliable results. We need to obtain blood samples from at least 4 people in a family (Mother and Father and 2 children).

Specific volunteer requirements:

  • You must have (or have had) alopecia areata and be willing to provide a blood sample.
  • You must have a genetically related brother or sister who has (or has had) alopecia areata and is willing to provide a blood sample.
  • You and your brother or sister must not be monozygotic twins (identical twins).
  • It is not necessary for your genetically related mother and father to have alopecia areata, but they must be willing to each provide a blood sample.
  • Individuals with trisomy 21 (Down’s syndrome) are not able to take part in the study as the additional chromosome 21 DNA would bias the statistical analysis.
  • You should be resident in Europe, Scandinavia, Taiwan, Australia, or Singapore. We are currently investigating methods to include individuals from other geographic regions, but at this time we have no system to collect blood or data from volunteers located outside Europe, Scandinavia, Taiwan, Australia, and Singapore.

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